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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized by their focus on practical aspects of design, including recruitment and consent, adherence and the use routinely available equipment.

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A pragmatic trial that uses a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for practical trials to be valid, and it also reduces bias in the results. A high degree of heterogeneity, however could cause issues with the design of the trial.

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Pragmatic Play is known for its top-notch games, and for providing a superior user experience. The software is available on mobile devices and in a variety of languages. It has been recognized as one of the most popular casino gaming platforms despite its relative infancy. The most recent releases include Wolves which is a five-reel video slot with a healthful RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. Usually, they are ordered by policymakers and practitioners in order to guide their decisions. They can also be used to assess the cause-effect relationship of an intervention and its results. However, they should not be used as a substitute for explanatory studies.

The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study, including recruitment, design, delivery of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority of these studies were conducted in primary-care settings.