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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are often characterized as a focus on the practical aspects of study design that include recruitment and consent, adherence and the use of standard equipment.

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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity and helps to reduce the chance of bias in the results. However, too much heterogeneity can lead to issues with the design of the trial.

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Mobile compatibility

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Pragmatic Play offers a large number of games you can play for free before you decide whether or not to purchase them. The games for free are designed to play on all kinds of devices from tablets to desktops and smartphones. They can be played anywhere you're connected to the internet. They are easy to navigate. Some Pragmatic Play websites even let you test your luck while on the move by playing a test mode. This can help you familiarize yourself with the game's rules and features prior to playing for real money.

Legality

Pragmatic Play is known for its top-quality games and also for providing an outstanding user experience. Its software is accessible on mobile devices as well as in various languages. It has earned itself the status of one of the most popular gaming platforms in the casino industry despite its relatively young age. The latest releases include Wolves, a 5-reel video slot that has a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically commissioned by practitioners and policy makers to inform their decision making. They can also be used to determine the causal relationship between an intervention and its results. However, they should not be used in lieu for explanation trials.

The pragmatism concept is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made the distinction between explanation studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform the decision-making process for policy and practice. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool sought to define the features of a practical trial which includes the recruitment process, the design and delivery of the intervention, as well as follow-up.

There is a growing trend in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. However, it is important to remember that the majority of these trials were conducted in primary care settings.